- In recent years, the pivotal role of oxidative stress in onset of BPD has emerged clearly: oxidative stress influences gene expression responsible for arrest of alveolarization and abnormal lung vascular development typical of the “new BPD.” It is crucial to understand the molecular mechanisms that drive to the disease in order to achieve therapies based on a pathogenic approach.
- Microbiomics, metabolomics and proteomics are important sources of findings about the modifications that occurs in the lungs. Modifications in lung microbioma are showing to be correlated with the pathogenesis of BPD. Metabolomics could be useful to detect a “fingerprint” able to identify at birth preterm babies at risk of developing BPD. Proteomics shows that enzymes protecting against oxidative stress are down regulated in BPD infants, thus antioxidant therapy may be a potential treatment.
- In future, “omics” will help in screening the preterm newborns more susceptible to BPD and potentially treat them in an individualized fashion.
Oxidative Stress and Bronchopulmonary Dysplasia: Evidences From Microbiomics, Metabolomics, and Proteomics DOWNLOAD VIEW ONLINE